Determination of required hydrophilic-lipophilic balance of <i>Amesiodendron chinense</i> (Merr.) Hu oil and development of stable cream formulation

Amesiodendron chinense (Merr.) Hu oil is reported to use for the treatment of skin disease by Thai folk medicine. Its hydrophilic-lipophilic balance (HLB) value very important developing a stable cream formulation. This study aimed determine required (rHLB) and develop Herbal containing was prepared phase inversion temperature technique using water, Tween80, Span60. The first series 11 emulsions with HLB values ranging from 5.0 15.0 second eight smaller interval in 7.8 were prepared. rHLB coconut also determined validation methodology. Creaming index established parameter emulsion. Emulsions optimum emulsifier concentration resulted less percentage-creaming index. Utilizing rHLB, formulated evaluated different physical parameters including viscosity, color, odor, texture, pH. Finally, results showed 5.4 6.2, respectively. creams developed 3% emulsifier. Physical found be consistent over 6 cycles accelerated stability test under 4 45 ○ C. properties evaluation ensure cream. exhibited, successfully utilizing rHLB.